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The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling regulates various biological effects including calcium and the metabolism of phosphorous, parathormone production cells’ proliferation, parathormone secretion, and control of innate and adaptive immunity.

A T >C change in the promoter of VDR variant (rs11568820) removes the binding site of the transcription factor Cdx2 just upstream of exon 1. This results in a less pronounced protein with reduced transcriptional activity. The F variant is found in high frequency among Asians and Europeans and in low frequencies among Africans from Sub-Saharan Africa.

The findings of this study enhance our understanding of how VDR gene polymorphisms affect the response to dietary supplements containing calcitriol. The carriers of the TaqI polymorphism, as well as the FF genotype of the FokI polymorphism have higher oldetowntimes.net/sims-4-debug-cheat-codes-get-the-most-out-of-your-game transcriptional activation of VDR and are associated with better calcium absorption and bone mineral density as well as an increase in the risk of fractures [34 35, 34]. To better understand the role that these genetic variations play in the supplementation of vitamin D we must conduct more research with a homogeneous design.